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• 产品描述： SAR7334是一种新型，高效且可生物利用的TRPC6通道抑制剂。SAR7334在膜片钳实验中阻断了TRPC6电流，IC50为7.9 nM

• 靶点： TPRC6(Cell-free assay):7.9nM;TRP/TRPVChannel

• 体外研究：
  SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected..SAR7334 suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice

• 体内研究：
  Pharmacokinetic studies of SAR7334 demonstrates that the compound was suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)

• 细胞实验： Cell lines: HEK cells Concentrations: '-- Incubation Time: 10min Method: The cells are rinsed and incubated with standard extracellular solution supplemented with different concentrations of the test compound or vehicle for 10 min.

• 动物实验： Animal Models: Sprague Dawley rat Dosages: 10mg/kg Administration: oral

• 参考文献：
  1. Maier T,et al.Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol.2015;172(14):3650-60

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.718 ml	13.592 ml	27.183 ml
  5 mM	0.544 ml	2.718 ml	5.437 ml
  10 mM	0.272 ml	1.359 ml	2.718 ml
  50 mM	0.054 ml	0.272 ml	0.544 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *