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S83669

NIBR189

源叶(MedMol) 99%
  • 英文名:
  • NIBR189
  • 别名:
  • (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one; NIBR189;
  • CAS号:
  • 1599432-08-2
  • 分子式:
  • C21H21BrN2O3
  • 分子量:
  • 429.307
  • 核磁/质谱:
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源叶(MedMol) S83669-2mg 99% ¥200.00元 5 - - - EA 加入购物车
源叶(MedMol) S83669-5mg 99% ¥260.00元 5 - - - EA 加入购物车
源叶(MedMol) S83669-10mg 99% ¥420.00元 4 - - - EA 加入购物车
源叶(MedMol) S83669-50mg 99% ¥1350.00元 7 - - - EA 加入购物车
源叶(MedMol) S83669-100mg 99% ¥2100.00元 6 - - - EA 加入购物车
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参考文献

质检证书(COA)

摩尔浓度计算器

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  • 提示:详情请下载说明书。
  • 产品描述: NIBR189 是 Epstein-Barr virus-induced gene 2 (EBI2, GPR183) receptor 的有效拮抗剂,其结合的IC50值为16 nM,其功能的IC50值为11 nM
  • 靶点: EBI2 (function)(Cell-free assay):11 nM; EBI2 (binding)(Cell-free assay):16 nM;EBI2/GPR183
  • 体外研究:
    NIBR189, the EBI2 antagonist, blocks the migration of U937 cells expressing functional EBI2 levels with an IC50 of 0.3 nM
  • 体内研究:
    NIBR189 is a potent and selective EBI2 antagonist with pharmacokinetic properties which should allow use for in vitro and in vivo experiments
  • 细胞实验: Cell lines: U937 cells Concentrations: 20 nM Incubation Time: 3 h Method: Prior to the migration assay, U937 cells were kept overnight in lipid-depleted media. Chemotaxis was performed using HTS Transwell-96 plates with 5.0 μm pore polycarbonate membranes. In brief, lower chambers were filled with 240 μL of compound solution in media in which the FCS was substituted with 1% BSA, and after insertion of the filters, 0.75×105 cells in 75 μL media were added to the upper chamber. After 3 h at 37℃, cells in the lower chamber were analyzed by flow cytometry.
  • 动物实验: Animal Models: C57BL/6 male mice Dosages: 1 mg/kg (i.v.); 3 mg/kg (p.o.) Administration: i.v., p.o.
  • 参考文献:
    1. Francois Gessier, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014 Apr 24;57(8):3358-68.
  • 溶解性: Soluble  in  DMSO、Ethanol
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.329 ml 11.647 ml 23.293 ml
    5 mM 0.466 ml 2.329 ml 4.659 ml
    10 mM 0.233 ml 1.165 ml 2.329 ml
    50 mM 0.047 ml 0.233 ml 0.466 ml
  • 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)


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