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S84873

Hycanthone

源叶(MedMol) 98%
  • 英文名:
  • 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE
  • 别名:
  • 海恩酮;1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-9h-thioxanthen-9-on;1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one;hycanthon;lucanthonemetabolite;nsc-134434;HYCANTHONE;1-[(
  • CAS号:
  • 3105-97-3
  • 分子式:
  • C20H24N2O2S
  • 分子量:
  • 356.48
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S84873-10mg 98% ¥500.00元 预计交期:2-3天 - - - EA 加入购物车
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参考文献

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  • 提示:详情请下载说明书。
  • 产品描述: Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a KD of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone (HY-B2098) and has anti-schistosomal agent
  • 靶点: Topoisomerase I;Topoisomerase II;DNA/RNASynthesis;Topoisomerase;Parasite
  • 体内研究:
    Results show that the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease after treatment with Hycanthone. Immature worms are totally unaffected by Hycanthone at all times tested. Male worms treated with Hycanthone show signs of a possible partial recovery from the initial low levels of incorporation. The incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50% in the first four days after treatment. Results show that, 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules
  • 参考文献:
    1. Mamta D Naidu, et al. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One. 2011;6(9):e23679. 2. Pica Mattoccia L, et al. Effect of hycanthone administered in vivo upon the incorporation of radioactive precursors into macromolecules of Schistosoma mansoni. Mol Biochem Parasitol. 1983 Jun;8(2):99-107. 3. Hahon N, et al. Action of antischistosomal drugs, hycanthone and its analog 1A-4 N-oxide, on viral interferon induction. J Toxicol Environ Health. 1980 Jul;6(4):705-12.
  • 溶解性: Soluble  in  DMSO
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.805 ml 14.026 ml 28.052 ml
    5 mM 0.561 ml 2.805 ml 5.61 ml
    10 mM 0.281 ml 1.403 ml 2.805 ml
    50 mM 0.056 ml 0.281 ml 0.561 ml
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