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• 产品描述： ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of agent

• 靶点： IC50: 76 μM (TrioN);Rho

• 体外研究：
  ITX3 (5, 10, 25, 50 and 100 μM; 24 h) inhibits TrioN signaling. ITX3 (50 μM; 1 h) specifically inhibits TrioN. ITX3 (100 μM; 36 h) inhibits nerve growth factor-induced neurite outgrowth in PC12 cells. ITX3 (1, 10 and 100 μM) represses Rac1 activity and dose-dependently up-regulates the E-cadherin protein level and phospho-p38 signal in Tara-KD cells. Western Blot Analysis Cell Line: TrioN-, GEF337-, Tiam1- and Vav2-expressing HEK293 cell lines Concentration: 50 μM Incubation Time: 1 hour Result: Decreased TrioN-induced Rac activity.

• 参考文献：
  1. Bouquier N, et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol. 2009 Jun 26;16(6):657-66. 2. Yano T, et al. Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J Cell Biol. 2011 Apr 18;193(2):319-32.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.692 ml	13.461 ml	26.921 ml
  5 mM	0.538 ml	2.692 ml	5.384 ml
  10 mM	0.269 ml	1.346 ml	2.692 ml
  50 mM	0.054 ml	0.269 ml	0.538 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *