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S85073

5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE

源叶(MedMol) 98%
  • 英文名:
  • 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE
  • 别名:
  • 5ˊ-异丁硫基-5ˊ-脱氧腺苷;5ˊ-S-(2-甲基丙基)-5ˊ-硫代腺苷;5ˊ-脱氧-5ˊ-S-异丁基硫代腺苷;5ˊ-异丁硫基-5ˊ-脱氧腺苷;5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE;5’-deoxy-5’-s-isobutylthioadenosine;5''-Deoxy-5''-S-isobutyladenosine;5μ-Deoxy-5μ-S-isobutylt
  • CAS号:
  • 35899-54-8
  • 分子式:
  • C14H21N5O3S
  • 分子量:
  • 339.418
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S85073-5mg 98% ¥1131.00元 10 - - - EA 加入购物车
源叶(MedMol) S85073-25mg 98% ¥4118.00元 7 - - - EA 加入购物车
源叶(MedMol) S85073-100mg 98% ¥7200.00元 3 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies
  • 靶点: Plasmodium;HSV-1;NucleosideAntimetabolite/Analog;HSV
  • 体内研究:
    SIBA (150 mg/kg; i.p.; twice weekly for 3 weeks) inhibits tumor growth in vivo. SIBA (15 mg/kg; i.p.; thrice weekly for 4 weeks) inhibits metastatic spread of RMS-J1 cells in vivo Animal Model: C57BL/6 female mice (4-8 weeks old). Dosage: 150 mg/kg Administration: Intraperitoneal injection; twice weekly for 3 weeks. Result: Significantly reduced the median number of lung metastases.
  • 参考文献:
    1. F Breillout , et al. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis. Jan-Feb 1988;6(1):3-16. 2. B Jacquemont, et al. Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine. J Virol. 1977 Apr;22(1):160-7. 3. Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts. Biochem J. 1982 Jun 15;204(3):853-9.
  • 溶解性: Soluble  in  DMSO
  • 保存条件: -20°C
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.946 ml 14.731 ml 29.462 ml
    5 mM 0.589 ml 2.946 ml 5.892 ml
    10 mM 0.295 ml 1.473 ml 2.946 ml
    50 mM 0.059 ml 0.295 ml 0.589 ml
  • 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
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