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• 产品描述： CASIN (Pirl1-related Compound 2) 可直接抑制 Cdc42/RhoGDI 的激活，其IC50值为2 μM

• 靶点： Cdc42/RhoGDI(Cell-free assay):2 μM;CDK;STAT;Ras

• 体外研究：
  CASIN facilitates the eradication of ALL LSCs by AraC + QC and prolongs the survival of both primary and secondary recipients without affecting long-term normal human hematopoiesis

• 体内研究：
  The combination of CASIN with the AraC + QC regimen eliminates quiescent LSCs and prolongs the survival of xenografted mice

• 细胞实验： Cell lines: Human ALL cell line Molt4-Luc2 expressing luciferase maker Concentrations: 5 μM Incubation Time: -- Method: For in vitro studies, CASIN (containing 0.02-0.2% DMSO) was used at 5 μM in the culture medium.

• 动物实验： Animal Models: Humanized NSGS mice expressing transgenic cDNA encoding human SCF, GM-SCF, and IL-3 (NOD SCID IL-2Rγ -/- SCF, GM-CSF, and IL-3) 36 Dosages: 2.4 mg/kg Administration: i.p.

• 参考文献：
  1. Jeffrey R Peterson, et al. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. nChem Biol. 2006 Apr;13(4):443-52. 2. Wu L, et al. Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia. Nat Commun. 2021 Nov 26;12(1):6936.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.264 ml	16.319 ml	32.637 ml
  5 mM	0.653 ml	3.264 ml	6.527 ml
  10 mM	0.326 ml	1.632 ml	3.264 ml
  50 mM	0.065 ml	0.326 ml	0.653 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *