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• 产品描述： Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K+ channel with an IC50 of 19.9 μM.

• 靶点： Plasmodium;PotassiumChannel;SodiumChannel;Parasite

• 体内研究：
  Direct application of Quinidine hydrochloride monohydrate on the sciatic nerve produces a dose-related decrease in amplitude at ascending somato-sensory evoked potential (SSEP) and descending compound muscle action potentials (CMAP) when comparing baseline with other time points, or when comparing the experimental left limb to the right contra-lateral glucose-treated limb. The latencies of SSEPs and CMAP potentials after Quinidine hydrochloride monohydrate applications are increased compare to baseline and the contralateral side

• 参考文献：
  1. Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63. 2. Cheng KI, et al. Application of quinidine on rat sciatic nerve decreases the amplitude and increases the latency of evoked responses. J Anesth. 2014 Aug;28(4):559-68.

• 溶解性： Soluble  in  DMSO、H2O

• 保存条件： RT;充氩

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.771 ml	13.855 ml	27.71 ml
  5 mM	0.554 ml	2.771 ml	5.542 ml
  10 mM	0.277 ml	1.386 ml	2.771 ml
  50 mM	0.055 ml	0.277 ml	0.554 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *