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• 产品描述： RSV-604 is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM)

• 靶点： RSV

• 体外研究：
  RSV-604 increases viability of RSV-infected HEp-2 cells (EC50 = 0.86 μM) and inhibits RSV replication in human airway epithelial (HAE) cell monolayers following mucosal inoculation

• 体内研究：
  RSV604 resistance mutations in the N protein. RSV604 engaged in two different MoAs in HeLa cells, inhibiting both RSV RNA synthesis and the infectivity of released virus. RSV604 did not inhibit viral RNA synthesis in the RSV subgenomic replicon cells or in the cell-free RNP assay, suggesting that it might act prior to viral replication complex formation. RSV604 did not alter N protein localization in the infected cells

• 参考文献：
  1. RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication[J]. Antimicrobial Agents and Chemotherapy, 2007, 51(9):3346-3353. 2. Challa S, Scott AD, Yuzhakov O,et al.Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604[J].Antimicrob Agents Chemother. 2015 Feb

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.575 ml	12.874 ml	25.747 ml
  5 mM	0.515 ml	2.575 ml	5.149 ml
  10 mM	0.257 ml	1.287 ml	2.575 ml
  50 mM	0.051 ml	0.257 ml	0.515 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *