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S86474

Acamprosate Calcium

源叶(MedMol) 98%
  • 英文名:
  • Acamprosate Calcium
  • 别名:
  • CAS号:
  • 77337-73-6
  • 分子式:
  • 2(C5H10NO4S).Ca
  • 分子量:
  • 400.48
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S86474-25mg 98% ¥204.00元 7 - - - EA 加入购物车
源叶(MedMol) S86474-50mg 98% ¥295.00元 7 - - - EA 加入购物车
源叶(MedMol) S86474-200mg 98% ¥637.50元 2 - - - EA 加入购物车
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产品介绍

参考文献

质检证书(COA)

摩尔浓度计算器

相关产品

  • 产品描述: Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate,N-acetylhomotaurinate)是一种合成化合物,具有和氨基酸神经转运体GABA、氨基酸神经调质taurine类似的化学结构。
  • 靶点: GABAReceptor
  • 体内研究:
    Acamprosate is absorbed via the gastrointestinal tract, with pharmacokinetic linearity in terms of dose and time. Absolute bioavailability of acamprosate under fasting conditions is approximately 11%. After food intake, bioavailability decreases by approximately 20%, but this decrease lacks clinical significance. Steady-state plasma concentrations of acamprosate are reached within 5 days of dosing and the terminal half-life ranges from 20–33 hours following the standard 2 × 333 dosing regime. Plasma protein binding is negligible. Acamprosate is not metabolized in the liver and is excreted unchanged in the urine. Acamprosate may have neuroprotective effects. Acamprosate appears to work by normalizing the dysregulation of NMDA-mediated glutamatergic neurotransmission that occurs during chronic alcohol consumption and withdrawal, and thus attenuates one of the physiological mechanisms that may prompt relapse
  • 参考文献:
    1.Barbara J Mason, et al. CNS Neurol Disord Drug Targets. 2010, 9(1): 23–32.
  • 溶解性: Soluble  in  H2O
  • 保存条件: RT
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.497 ml 12.485 ml 24.97 ml
    5 mM 0.499 ml 2.497 ml 4.994 ml
    10 mM 0.25 ml 1.249 ml 2.497 ml
    50 mM 0.05 ml 0.25 ml 0.499 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)


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