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• 产品描述：

  JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine

• 靶点： TRPV1;TRP/TRPVChannel

• 体内研究：
  JNJ-17203212 (0.3 mg/kg; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression. JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner. Animal Model: Male Sprague-Dawley rats (260-300 g) Dosage: 0.3 mg/kg Administration: Intravenous injection Result: Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS.

• 参考文献：
  1. Xingjuan Chen, et al. Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel.J Biol Chem. 2014 Apr 4; 289(14): 9600-9610. 2. Jannis E Meents, et al. Two TRPV1 receptor antagonists are effective in two different experimental models of migraine. J Headache Pain. 2015; 16: 57.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.387 ml	11.933 ml	23.866 ml
  5 mM	0.477 ml	2.387 ml	4.773 ml
  10 mM	0.239 ml	1.193 ml	2.387 ml
  50 mM	0.048 ml	0.239 ml	0.477 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *