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• 产品描述： H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.

• 靶点： ROCKII:12 nM (IC50);CaMKII:0.18 μM (IC50);PKG:0.36 μM (IC50);AuroraA:0.745 μM (IC50);PKA:3.03 μM (IC50);Src:3.06 μM (IC50);PKC:5.68 μM (IC50);Abl:7.77 μM (IC50);MKK4:16.9 μM (IC50);MLCK:28.3 μM (IC50);EGFR:50 μM (IC50);GSK3α:60.7 μM (IC50);AMPK:100 μM (IC50);P38α:100 μM (IC50);ROCK

• 参考文献：
  1. Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. Epub 2005 Sep 12. 2. Ikenoya M, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr;81(1):9-16. 3. Lie M, et al. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010 Aug 25;169(2):855-62.

• 溶解性： Soluble  in  DMSO、H2O

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.549 ml	12.744 ml	25.488 ml
  5 mM	0.51 ml	2.549 ml	5.098 ml
  10 mM	0.255 ml	1.274 ml	2.549 ml
  50 mM	0.051 ml	0.255 ml	0.51 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *