• 产品描述： LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models

• 靶点： NOP Receptor/ORL1;OpioidReceptor

• 体内研究：
  LY2940094 (3、10 或 30 mg/kg；2-3 mL/kg；每天口服；持续 4 天) 剂量依赖性地减少印第安纳州酒精偏好 (P) 和马尔基吉安撒丁岛酒精偏好 (msP) 大鼠，不影响食物/水的摄入或运动活动。 Animal Model: Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)[1] Dosage: 3, 10, or 30 mg/kg; 2-3 mL/kg Administration: Administered orally; daily; 4 days Result: Reduced homecage ethanol self-administration.

• 参考文献：
  1. Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.079 ml	10.396 ml	20.792 ml
  5 mM	0.416 ml	2.079 ml	4.158 ml
  10 mM	0.208 ml	1.04 ml	2.079 ml
  50 mM	0.042 ml	0.208 ml	0.416 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *