• 产品描述： Avacopan (CCX168) 是一种口服的选择性的 C5a receptor (C5aR) 的拮抗剂。

• 靶点： C5aR;ComplementSystem

• 体外研究：
  Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.

• 体内研究：
  Cell lines: RAW 264.7 cells Concentrations: 1 µM Incubation Time: 24 h Method: Cells were treated with indicated concentrations of drug for 24 h.

• 细胞实验： Animal Models: C57B6/6J (B6) and C3H/HeJ mice Dosages: 30 mg/kg Administration: o.g.

• 参考文献：
  1. David R W Jayne, et al. Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis. J Am Soc Nephrol. 2017 Sep;28(9):2756-2767. 2. Brandolini L, et sl. Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions. Cell Death Dis. 2022 May 25;13(5):500. 3. Xiao H, et al. C5a receptor (CD88) blockade protects against MPO-ANCA GN. J Am Soc Nephrol. 2014 Feb;25(2):225-31.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.719 ml	8.596 ml	17.193 ml
  5 mM	0.344 ml	1.719 ml	3.439 ml
  10 mM	0.172 ml	0.86 ml	1.719 ml
  50 mM	0.034 ml	0.172 ml	0.344 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *