• 提示：详情请下载说明书。

• 产品描述： (-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

• 靶点： PKCη-CRD2:3.36 nM (Ki);PKCη-C1B:5.5 nM (Kd);PKCε-C1B:7.7 nM (Kd);PKCδ-C1B:8.3 nM (Kd);PKCθ-C1B:8.7 nM (Kd);PKCβ-C1A-long:18.9 nM (Kd);PKCα-C1A-long:20.8 nM (Kd);PKCβ-C1B:137 nM (Kd);PKCγ-C1A:138 nM (Kd);PKCγ-C1B:213 nM (Kd);PKCγ-CRD2:1030 nM (Ki);PKCδ-C1A:1900 nM (Kd);PKCη-C1A:3770 nM (Kd);PKCα-C1B-long:4000 nM (Kd);PKCε-C1A:4110 nM (Kd);PKC

• 参考文献：
  1. Nakagawa Y, et al. Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V. Biosci Biotechnol Biochem. 1997 Aug;61(8):1415-7. 2. Masuda A, et al. Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7. 3. Chen S, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr;5(4):258-65.

• 溶解性： Soluble  in  DMSO

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.318 ml	16.59 ml	33.181 ml
  5 mM	0.664 ml	3.318 ml	6.636 ml
  10 mM	0.332 ml	1.659 ml	3.318 ml
  50 mM	0.066 ml	0.332 ml	0.664 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *