| 产品描述： | MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease |
| 靶点： |
Smo |
| 体外研究： |
MRT-83 (hydrochloride) (compound 86) has IC50s of 15 and 11 nM respectively in Shh-light2 and C3H10T1/2 cells in the biological activity assay. |
| 参考文献： |
1. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-20℃ |
| 备注： |
1. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571. |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.739 ml |
8.695 ml |
17.39 ml |
| 5 mM |
0.348 ml |
1.739 ml |
3.478 ml |
| 10 mM |
0.174 ml |
0.869 ml |
1.739 ml |
| 50 mM |
0.035 ml |
0.174 ml |
0.348 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京