| 品牌 | 货号 | 产品规格 | 价格(RMB) | 库存（上海） | 北京 | 武汉 | 南京 | 购买数量 |
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| 源叶(MedMol) | S23454-10mg | 98% | ￥400.00元 | 10 | - | - | - |
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| 源叶(MedMol) | S23454-25mg | 98% | ￥580.00元 | 5 | - | - | - |
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| 源叶(MedMol) | S23454-50mg | 98% | ￥1000.00元 | 预计交期：2-3天 | - | - | - |
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| 产品描述： CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease | ||||||||||||||||||||
| 靶点： PPARα;mouse she:11.1 nM (IC50);human she:112 nM (IC50);PPAR;EpoxideHydrolase | ||||||||||||||||||||
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体外研究： CUDA (10 μM; 18 hours) produces 6- and 3-fold increases of PPARalpha in COS-7 cells. CUDA does not alter PPARalpha protein expression, and it competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, suggesting that it functions as a PPARalpha ligand. |
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参考文献： 1. Morisseau C, et al. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochem Pharmacol. 2002 May 1;63(9):1599-608. 2. Fang X, et al. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther. 2005 Jul;314(1):260-70. |
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| 溶解性： Soluble in DMSO | ||||||||||||||||||||
| 保存条件： 2-8℃ | ||||||||||||||||||||
配置溶液浓度参考：
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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