货号	规格	价格	上海	北京	武汉	南京
S80014-1mg	98.9%	￥60.00 S80014-1mg ￥60.00 现货	9 9	-	-	-
S80014-2mg	98.9%	￥80.00 S80014-2mg ￥80.00 现货	10 10	-	-	-
S80014-5mg	98.9%	￥110.00 S80014-5mg ￥110.00 现货	10 10	-	-	-
S80014-10mg	98.9%	￥180.00 S80014-10mg ￥180.00 现货	6 6	-	-	-
S80014-25mg	98.9%	￥320.00 S80014-25mg ￥320.00 现货	6 6	-	-	-
S80014-50mg	98.9%	￥630.00 S80014-50mg ￥630.00 现货	4 4	-	-	-
S80014-100mg	≥98%	￥1020.00 S80014-100mg ￥1020.00 2-3天	0 货期：2-3天	-	-	-

大包装询价收藏产品

加入购物车

产品介绍

Vistusertib (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes.

产品描述：

Vistusertib (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes.

靶点：

mTOR:2.81 nM (IC50);mTORC1;mTORC2;PI3Kα:3.766 μM (IC50);Autophagy;Apoptosis;Akt;PI3K;S6Kinase;mTOR;Autophagy

体内研究：

Vistusertib (AZD2014) induces dose-dependent tumor growth inhibition in several xenograft and primary explant models. The antitumor activity of Vistusertib (AZD2014) is associated with modulation of both mTORC1 and mTORC2 substrates, consistent with its mechanism of action. The pharmacokinetics of Vistusertib (AZD2014) in mice is tested upon administration of doses between 7.5 and 15 mg/kg. A dose-dependent increase in Cmax and AUC is observed following single dose and repeat dosing of AZD2014: Cmax range from 1 to 16 μM and AUC range from 220 to 5,042 μM·h across this dose range. The pharmacodynamic effect of Vistusertib (AZD2014) against an mTORC1 biomarker (phosphorylation of S6) and an mTORC2 biomarker (phosphorylation of AKT) is assessed in SCID mice bearing MCF7 xenografts following administration of 3.75, 7.5, and 15 mg/kg AZD2014. There is a good relationship between the drug plasma concentrations and biomarker levels (estimated p-AKT IC50 of 0.119 μM total, 53% SE, and estimated p-S6 IC50 0.392 μM, 28.8% SE)

参考文献：

1. Guichard SM, et al. AZD2014, an inhibitor of mTORC1 and mTORC2, is highly effective in ER+ breast cancer when administered using intermittent or continuous schedules. Mol Cancer Ther. 2015 Nov;14(11):2508-18.

溶解性：

DMSO : ≥ 50 mg/mL (108.10 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.162 ml	10.81 ml	21.62 ml
5 mM	0.432 ml	2.162 ml	4.324 ml
10 mM	0.216 ml	1.081 ml	2.162 ml
50 mM	0.043 ml	0.216 ml	0.432 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置