Quetiapine

    
98%

Quetiapine

源叶(MedMol)
S80103 一键复制产品信息
111974-69-7
C21H25N3O2S
383.51
喹硫平;11-[4-[2-(2-羟基乙氧基)乙基]-1-哌嗪基]二苯并[b,f][1,4]硫氮杂卓
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80103-10mg 98% ¥227.00 2 - - -
S80103-50mg 98% ¥630.00 4 - - -
S80103-100mg 98% ¥990.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects

产品描述: Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects
靶点: 5-HT1A Receptor:5.74 (pKi);5-HT2A Receptor:7.54 (pKi);5-HT2C Receptor:5.55 (pKi);D2 Receptor:7.25 (pKi);5-HT1A Receptor:4.77 (pEC50);D2 Receptor:6.33 (pIC50);DopamineReceptor;5-HTReceptor;AdrenergicReceptor;AChR;HistamineReceptor
体内研究: Quetiapine (10 mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination
参考文献: 1. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. 2. Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.
溶解性: Soluble  in  DMSO、H2O、Ethanol
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.607 ml 13.037 ml 26.075 ml
5 mM 0.521 ml 2.607 ml 5.215 ml
10 mM 0.261 ml 1.304 ml 2.607 ml
50 mM 0.052 ml 0.261 ml 0.521 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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