• 产品描述： Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects

• 靶点： 5-HT1A Receptor:5.74 (pKi);5-HT2A Receptor:7.54 (pKi);5-HT2C Receptor:5.55 (pKi);D2 Receptor:7.25 (pKi);5-HT1A Receptor:4.77 (pEC50);D2 Receptor:6.33 (pIC50);DopamineReceptor;5-HTReceptor;AdrenergicReceptor;AChR;HistamineReceptor

• 体内研究：
  Quetiapine (10 mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination

• 参考文献：
  1. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. 2. Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.

• 溶解性： Soluble  in  DMSO、H2O、Ethanol

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.607 ml	13.037 ml	26.075 ml
  5 mM	0.521 ml	2.607 ml	5.215 ml
  10 mM	0.261 ml	1.304 ml	2.607 ml
  50 mM	0.052 ml	0.261 ml	0.521 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *