货号	规格	价格	上海	北京	武汉	南京
S80122-5mg	99%	￥410.00 S80122-5mg ￥410.00 现货	9 9	-	-	-
S80122-10mg	99%	￥700.00 S80122-10mg ￥700.00 现货	10 10	-	-	-
S80122-50mg	99%	￥2390.00 S80122-50mg ￥2390.00 现货	6 6	-	-	-

产品介绍

SNS-314 mesylate is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively

产品描述：

SNS-314 mesylate is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively

靶点：

Aurora A:9 nM (IC50);Aurora B:31 nM (IC50);Aurora C:6 nM (IC50);AuroraKinase

体内研究：

In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off

参考文献：

1. Oslob JD, et al. Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4. 2. Arbitrario JP, et al. SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17.

溶解性：

DMSO : 150 mg/mL (284.61 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.897 ml	9.487 ml	18.974 ml
5 mM	0.379 ml	1.897 ml	3.795 ml
10 mM	0.19 ml	0.949 ml	1.897 ml
50 mM	0.038 ml	0.19 ml	0.379 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

SNS-314 Mesylate