源叶(MedMol)
S80152
一键复制产品信息
1195765-45-7
C23H20F3N5O2S2
519.56
N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Dabrafenib (GSK2118436) 97.96%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80152-5mg |
97.96% | ￥96.00 |
>10 | - | - | - | - |
|
S80152-10mg |
97.96% | ￥140.00 |
>10 | - | - | - | - |
|
S80152-25mg |
97.96% | ￥220.00 |
>10 | - | - | - | - |
|
S80152-50mg |
97.96% | ￥330.00 |
>10 | - | - | - | - |
|
S80152-100mg |
97.96% | ￥490.00 |
>10 | - | - | - | - |
|
| 产品描述： | Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | BRafV600E:0.6 nM (IC50);CRAF:5 nM (IC50);Raf | ||||||||||||||||||||
| 体内研究： | Dabrafenib-treated females have mostly immature reproductive tracts with no evidence of ovulation, similar to age-matched controls; however, DAB-treated females have keratinized and histologically open vaginas | ||||||||||||||||||||
| 参考文献： | 1. Greger JG, et al. Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther, 2012, 11(4), 909-920. 2. Lee S, et al. Anti-inflammatory effects of dabrafenib on polyphosphate-mediated vascular disruption. Chem Biol Interact. 2016 Jul 22. 3. Jung B, et al. Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses. BMB Rep. 2016 Apr;49(4):214-9. 4. Alexander M Menzies, et al. Dabrafenib and its potential for the treatment of metastatic melanoma. Drug Des Devel Ther. 2012; 6: 391–405. 5. Posobiec LM, et al. Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation. Birth Defects Res B Dev Reprod Toxicol. 2015 Dec;104(6):244-52. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 33 mg/mL (63.52 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献
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