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BYL719 99%

BYL719

源叶(MedMol)
S80182
1217486-61-7
C19H22F3N5O2S
441.47
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80182-1mg 99% ¥110.00元 9 - - -
源叶(MedMol) S80182-5mg 99% ¥200.00元 8 - - -
源叶(MedMol) S80182-25mg 99% ¥650.00元 6 - - -
源叶(MedMol) S80182-50mg 99% ¥960.00元 5 - - -
源叶(MedMol) S80182-100mg 99% ¥1510.00元 2 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Alpelisib (BYL-719) is a potent, selective, and orally active PI3Kα inhibitor. Alpelisib (BYL-719) shows efficacy in targeting PIK3CA-mutated cancer. Alpelisib (BYL-719) also inhibits p110α/p110γ/p110δ/p110β with IC50s of 5/250/290/1200 nM, respectively. Antineoplastic activity
产品描述: Alpelisib (BYL-719) is a potent, selective, and orally active PI3Kα inhibitor. Alpelisib (BYL-719) shows efficacy in targeting PIK3CA-mutated cancer. Alpelisib (BYL-719) also inhibits p110α/p110γ/p110δ/p110β with IC50s of 5/250/290/1200 nM, respectively. Antineoplastic activity
靶点: p110α:5 nM (IC50);p110β:1200 nM (IC50);p110δ:290 nM (IC50);p110γ:250 nM (IC50);p110α-H1047R:4 nM (IC50);p110α-E545K:4 nM (IC50);PI3K
体内研究:
Alpelisib (BYL-719) (12.5 mg/kg and 50 mg/kg for C57Bl/6J mice; 50 mg/kg for female Rj:NMRI-nude mice; oral administration; daily) significantly reduces tumor volumes and deposition of ectopic bone matrix. Alpelisib has moderate terminal elimination half-life (t1/2=2.9±0.2 h) for rat (1 mg/kg, iv)
参考文献:
1. Furet P, et al. Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3741-8. 2. Fritsch C, et al. Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials. Mol Cancer Ther. 2014 May;13(5):1117-29. 3. Gobin B, et al. BYL719, a new α-specific PI3K inhibitor: single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma. Int J Cancer. 2015 Feb 15;136(4):784-96.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.265 ml 11.326 ml 22.652 ml
5 mM 0.453 ml 2.265 ml 4.53 ml
10 mM 0.227 ml 1.133 ml 2.265 ml
50 mM 0.045 ml 0.227 ml 0.453 ml
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参考文献

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