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S80223

Tolterodine

源叶(MedMol) 94%
  • 英文名:
  • Tolterodine
  • 别名:
  • 托特罗定;6--2-[3-(二异丙胺基)-1-苯丙基]-4-甲基苯酚;(R)-2-[3-(二异丙胺基)-1-苯丙基]-4-甲基苯酚;托特罗定;-2-[3-[二(1-甲基乙基)氨基]-1-苯丙基]-4-甲基苯酚;托特罗定-D14;托特罗定(R)-2-[3-(二异丙胺基)-1-苯丙基]-4-甲基苯酚;DETRUSITOL;DETROL;(+)-(R)-2-[A-[2-(DIISOPROPYLAMINO
  • CAS号:
  • 124937-51-5
  • 分子式:
  • C22H31NO
  • 分子量:
  • 325.488
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S80223-5mg 94% ¥800.00元 预计交期:2-3天 - - - EA 加入购物车
源叶(MedMol) S80223-10mg 94% ¥1400.00元 预计交期:2-3天 - - - EA 加入购物车
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  • 产品描述: Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. IC50 Value: Target: mAChR in vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors. in vivo: Tolterodine was extensively metabolized in vivo. In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was decreased, and the number of animals crossing was increased
  • 靶点: mAChR
  • 参考文献:
    1. Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90(5):260-7. 2. Andersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26(6):528-35. 3. Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579(1-3):225-8.
  • 溶解性: Soluble  in  DMSO、Ethanol
  • 保存条件: 2-8℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 3.072 ml 15.362 ml 30.723 ml
    5 mM 0.614 ml 3.072 ml 6.145 ml
    10 mM 0.307 ml 1.536 ml 3.072 ml
    50 mM 0.061 ml 0.307 ml 0.614 ml
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