| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
| S80238-1mg | 99% | ￥120.00 | 10 | - | - | - |
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| S80238-2mg | 99% | ￥220.00 | 10 | - | - | - |
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| S80238-5mg | 99% | ￥500.00 | 9 | - | - | - |
|
| S80238-10mg | 99% | ￥800.00 | 10 | - | - | - |
|
| S80238-25mg | 99% | ￥1700.00 | 货期：2-3天 | - | - | - |
|
| S80238-50mg | 99% | ￥2800.00 | 货期：2-3天 | - | - | - |
|
| S80238-100mg | 99% | ￥4500.00 | 货期：2-3天 | - | - | - |
|
Molibresib (I-BET762; GSK525762) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
| 产品描述： | Molibresib (I-BET762; GSK525762) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM. | ||||||||||||||||||||
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| 靶点： | IC50: 32.5-42.5 nM (BET);EpigeneticReaderDomain | ||||||||||||||||||||
| 体内研究： | The antimyeloma activity of Molibresib (I-BET 762) is tested dosed orally in an in vivo systemic xenograft model generated by injecting OPM-2 cells into NOD-SCID mice. Daily oral doses of Molibresib up to 10 mg/kg and 30 mg/kg given every other day are well tolerated with no clear impact on body weight compared with vehicle control. The plasma hLC concentration is significantly reduced in mice treated with Molibresib | ||||||||||||||||||||
| 参考文献： | 1. Nicodeme E, et al. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468(7327):1119-23. 2. Asangani IA, et al. Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer. Nature. 2014 Jun 12;510(7504):278-82. 3. Chaidos A, et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood. 2014 Jan 30;123(5):697-705. | ||||||||||||||||||||
| 溶解性： | DMSO : 200 mg/mL (471.81 mM; Need ultrasonic) 1M HCl : 100 mg/mL (235.90 mM; ultrasonic and adjust pH to 1 with HCl) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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