• 产品描述： Ciclesonide(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.

• 靶点： Glucocorticoid Receptor;GlucocorticoidReceptor

• 细胞实验： Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02 μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS. (Only for Reference)

• 参考文献：
  1.Nonaka T, et al. BMC Pharmacol. 2007, 7:12. 2.Guo Z, et al. Am J Ther. 2006, 13(6):490-501.

• 溶解性： DMSO:54.1  mg/mL  (100  mM)    Ethanol:54.1  mg/mL  (100  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.849 ml	9.247 ml	18.495 ml
  5 mM	0.37 ml	1.849 ml	3.699 ml
  10 mM	0.185 ml	0.925 ml	1.849 ml
  50 mM	0.037 ml	0.185 ml	0.37 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *