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• 产品描述： Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation

• 靶点： IC50: YAP-TEAD interaction;Apoptosis;YAP;VDA;Autophagy

• 体内研究：
  Verteporfin (10 mg/kg, c.s.c.) and BMS-354825 significantly reduces the leukemia cell ratio, and combined therapy further reduced the number of leukemia cells in the spleen

• 参考文献：
  1. Morishita T, et al. The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with BMS-354825. Oncotarget. 2016 Aug 2. 2. Pan W, et al. Verteporfin can Reverse the NSC 125973 Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression. Cell Physiol Biochem. 2016;39(2):481-90. 3. Donohue E, et al. The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.J Cancer. 2013 Aug 28;4(7):585-96.

• 溶解性： DMF  :  10  mg/mL  (13.91  mM;  ultrasonic  and  warming  and  heat  to  60°C)

• 保存条件： -20℃，充氮保存

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.391 ml	6.956 ml	13.912 ml
  5 mM	0.278 ml	1.391 ml	2.782 ml
  10 mM	0.139 ml	0.696 ml	1.391 ml
  50 mM	0.028 ml	0.139 ml	0.278 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=5] Zijun Guo et al."YAP/TEAD-induced PRIM1 contributes to the progression and poor prognosis of gastric carcinoma."Translational Oncology.10.1016/j.tranon.2023.101791

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *