| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
| S80258-1mg | 97%(HPLC) | ￥102.00 | 3 | - | - | - |
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| S80258-5mg | 97%(HPLC) | ￥391.00 | 4 | - | - | - |
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| S80258-10mg | 97%(HPLC) | ￥720.00 | 2 | - | - | - |
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| S80258-25mg | 97%(HPLC) | ￥1275.00 | 5 | - | - | - |
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| S80258-50mg | 97%(HPLC) | ￥2295.00 | 5 | - | - | - |
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| S80258-100mg | 97%(HPLC) | ￥3910.00 | 5 | - | - | - |
|
Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation
| 产品描述： | Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation | ||||||||||||||||||||
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| 靶点： | IC50: YAP-TEAD interaction;Apoptosis;YAP;VDA;Autophagy | ||||||||||||||||||||
| 体内研究： | Verteporfin (10 mg/kg, c.s.c.) and BMS-354825 significantly reduces the leukemia cell ratio, and combined therapy further reduced the number of leukemia cells in the spleen | ||||||||||||||||||||
| 参考文献： | 1. Morishita T, et al. The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with BMS-354825. Oncotarget. 2016 Aug 2. 2. Pan W, et al. Verteporfin can Reverse the NSC 125973 Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression. Cell Physiol Biochem. 2016;39(2):481-90. 3. Donohue E, et al. The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.J Cancer. 2013 Aug 28;4(7):585-96. | ||||||||||||||||||||
| 溶解性： | DMF : 10 mg/mL (13.91 mM; ultrasonic and warming and heat to 60°C) | ||||||||||||||||||||
| 保存条件： | -20℃，充氮保存 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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