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S80265

SKF-96365 hydrochloride

源叶(MedMol) 98%
  • 英文名:
  • SKF-96365 hydrochloride
  • 别名:
  • CAS号:
  • 130495-35-1
  • 分子式:
  • C22H27ClN2O3
  • 分子量:
  • 402.9144
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S80265-5mg 98% ¥323.00元 6 - - - EA 加入购物车
源叶(MedMol) S80265-10mg 98% ¥637.50元 7 - - - EA 加入购物车
源叶(MedMol) S80265-25mg 98% ¥1445.00元 6 - - - EA 加入购物车
源叶(MedMol) S80265-100mg 98% ¥3000.00元 预计交期:2-3天 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 inhibited hERG current in a concentration-dependent manner.
  • 靶点: Apoptosis;Autophagy;Calcium Channel;Potassium Channel;TRP/TRPV Channel;Apoptosis;PotassiumChannel;CalciumChannel;TRP/TRPVChannel;Autophagy
  • 体外研究:
    SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects.
  • 体内研究:
    SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a decrease of p-CaMKII and p-AKT as well as an increase in LC3-II, cleaved PARP, caspase-3, and caspase-9 in mice.
  • 细胞实验: To investigate whether SKF-96365 could protect PC12 cells from injury induced by MPP+ insult, cultured PC12 cells are pretreated with SKF-96365 in different concentrations (1 µM, 10 µM or 50 µM) 30 min before MPP+ addition. The cells viability is measured 24 h after MPP+ insult by using the cell proliferation reagent WST-1. (Only for Reference) Cell lines: PC12 cells
  • 参考文献:
    1. Chen T, et al. PLoS One. 2013, 8(1):e55601. 2. Yao H, et al. Cell Death Differ. 2009, 16(12):1681-1693. 3. Singh A, et al. Br J Pharmacol. 2010, 160(6):1464-1475. 4. Jing Z, et al. Cancer Lett. 2016, 372(2):226-38.
  • 溶解性: Soluble  in  DMSO、H2O
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.482 ml 12.41 ml 24.819 ml
    5 mM 0.496 ml 2.482 ml 4.964 ml
    10 mM 0.248 ml 1.241 ml 2.482 ml
    50 mM 0.05 ml 0.248 ml 0.496 ml
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