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产品描述： Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local anesthetic, with antipruritic effects |
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靶点：
H1 Receptor:1.01 mM (IC50);5-HTReceptor;HistamineReceptor |
体内研究：
Pheniramine maleate (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats |
参考文献：
1. Sharma A, et al. Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view. Curr Drug Metab. 2003 Apr;4(2):105-29. 2. Brown RD, et al. Alpha 1-adrenergic and H1-histamine receptor control of intracellular Ca2+ in a muscle cell line: the influence of prior agonist exposure on receptor responsiveness. Mol Pharmacol. 1986 Jun;29(6):531-9. 3. Jangi SM, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14(7-8):363-72. 4. Hung CH, et al. Spinal anesthesia with diphenhydramine and pheniramine in rats. Eur J Pharmacol. 2011 Dec 30;673(1-3):20-4. |
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溶解性：
H2O : ≥ 38 mg/mL (106.62 mM) |
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保存条件：
-20°C |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
2.806 ml |
14.028 ml |
28.057 ml |
| 5 mM |
0.561 ml |
2.806 ml |
5.611 ml |
| 10 mM |
0.281 ml |
1.403 ml |
2.806 ml |
| 50 mM |
0.056 ml |
0.281 ml |
0.561 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京