| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80287-1mg |
99.7% | ￥220.00 | 10 | - | - | - |
|
S80287-2mg |
99.7% | ￥350.00 | 10 | - | - | - |
|
S80287-5mg |
99.7% | ￥500.00 | 7 | - | - | - |
|
S80287-10mg |
99.7% | ￥890.00 | 6 | - | - | - |
|
S80287-25mg |
99.7% | ￥1800.00 | 5 | - | - | - |
|
S80287-50mg |
≥98% | ￥3200.00 | 货期：2-3天 | - | - | - |
|
S80287-100mg |
≥98% | ￥4900.00 | 货期：2-3天 | - | - | - |
|
XMD16-5 is a potent TNK2 inhibitor with IC50 values of 16 and 77 nM for the D163E and R806Q mutations, respectively.
| 产品描述： | XMD16-5 is a potent TNK2 inhibitor with IC50 values of 16 and 77 nM for the D163E and R806Q mutations, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 16 nM (TNK2, D163E mutation), 77 nM (TNK2, R806Q mutation);Tyrosinase;PPAR | ||||||||||||||||||||
| 体外研究： | XMD16-5 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD16-5 has IC50s of 16 nM and 77 nM for the D163E and R806Q mutations. The effects of XMD16-5 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD16-5 | ||||||||||||||||||||
| 参考文献： | 1. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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