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Strontium Ranelate 99%

Strontium Ranelate

源叶(MedMol)
S80295
135459-87-9
C12H6N2O8SSr2
513.49
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80295-100mg 99% ¥150.00元 10 - - -
源叶(MedMol) S80295-500mg 99% ¥350.00元 7 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling
产品描述: Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling
靶点: CaSR;CalciumChannel;CaSR
体内研究:
Strontium Ranelate increases bone formation and decreased bone resorption, which results in increased bone mass in the vertebrae of intact adult mice. In intact adult rats, Strontium Ranelate also increases bone mass, as measured by dual-energy X-ray absorptiometry, in lumbar vertebra and femur, and this is confirmed by histological assessment of trabecular bone volume in the tibial metaphysis. Strontium Ranelate is found to decrease bone resorption and to increase bone formation in alveolar bone in normal adult monkeys (Macaca fascicularis), which exhibits extensive bone remodeling. In ovariectomized rats, short-term (3 months) treatment with Strontium Ranelate prevents trabecular bone loss induced by oestrogen deficiency, as demonstrated by bone ash, bone mineral content and histomorphometric analysis in the tibial metaphysis. This effect results from decreased bone resorption while bone formation was maintained. These beneficial effects of Strontium Ranelate on bone mass and microarchitecture in ovariectomized rats are confirmed in long-term experiments. In this long-term study (2 years), the increase in bone mass and microarchitecture induced by Strontium Ranelate results in a marked improvement in bone strength, supporting the beneficial effect of this drug on bone resistance.
参考文献:
1. Bonnelye E, Chabadel A, Saltel F, Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2008 Jan;42(1):129-38. Epub 2007 Sep 12. 2. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5.
溶解性: 0.1  M  HCL  :  17.5  mg/mL  (34.08  mM;  ultrasonic  and  adjust  pH  to  3  with  HCl)    H2O  :  2  mg/mL  (3.89  mM;  ultrasonic  and  warming  and  heat  to  60°C)    DMSO  :  <  1  mg/mL  (insoluble  or  slightly  soluble)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.947 ml 9.737 ml 19.475 ml
5 mM 0.389 ml 1.947 ml 3.895 ml
10 mM 0.195 ml 0.974 ml 1.947 ml
50 mM 0.039 ml 0.195 ml 0.389 ml
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参考文献

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