Pimecrolimus

98.10%

Pimecrolimus

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品牌：源叶(MedMol)

产品编号：S80302 一键复制产品信息

CAS号：137071-32-0

分子式：C₄₃H₆₈ClNO₁₁

分子量：810.453

别名：吡美莫司;匹美克莫司;吡美莫司/匹美克莫司;匹美莫司;Picrolimus;ASM 981;Elidel;SDZ-ASM 981;Pimecrolimus;15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxyc

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80302-5mg	98.10%	￥210.00 S80302-5mg ￥210.00 现货	608 >10	-	-	-	-
S80302-10mg	98.10%	￥320.00 S80302-10mg ￥320.00 现货	307 >10	-	-	-	-
S80302-25mg	98.10%	￥480.00 S80302-25mg ￥480.00 现货	131 >10	-	-	-	-
S80302-100mg	98.10%	￥960.00 S80302-100mg ￥960.00 现货	37 >10	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a Ki of 117 nM. Pimecrolimus shows anti-inflammatory activity

靶点：

Calcineurin

体内研究：

Pimecrolimus (SDZ-ASM 981) (0-0.4%; topical; 10 μL once) inhibits allergic contact dermatitis in mice and pigs. Pimecrolimus (0-90 mg/kg; p.o. or s.c.; twice or once) potently inhibits allergic contact dermatitis in mice and rats.

参考文献：

1. Grassberger M, et al. Pimecrolimus -- an anti-inflammatory drug targeting the skin. Exp Dermatol. 2004 Dec;13(12):721-30. 2. Grassberger M, et al. A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology. Br J Dermatol. 1999 Aug;141(2):264-73. 3. Meingassner JG, et al. A novel anti-inflammatory drug, SDZ ASM 981, for the topical and oral treatment of skin diseases: in vivo pharmacology. Br J Dermatol. 1997 Oct;137(4):568-76.

溶解性：

DMSO : ≥ 32 mg/mL (39.48 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.234 ml	6.169 ml	12.339 ml
5 mM	0.247 ml	1.234 ml	2.468 ml
10 mM	0.123 ml	0.617 ml	1.234 ml
50 mM	0.025 ml	0.123 ml	0.247 ml