货号	规格	价格	上海	北京	武汉	南京	购买数量
S80370-100mg	98%	￥500.00 S80370-100mg ￥500.00 现货	4 4	-	-	-
S80370-500mg	98%	￥2040.00 S80370-500mg ￥2040.00 现货	4 4	-	-	-

产品介绍

Selegiline (Deprenyl) hydrochloride is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline hydrochloride exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline hydrochloride can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder

产品描述：

靶点：

MAO-B:51 nM (IC50)

体内研究：

Selegiline (1 mg/kg; i.p. daily for 24 days) hydrochloride reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline hydrochloride reduces 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex

参考文献：

1. Chaurasiya ND, et, al. Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana). Molecules. 2019 Feb 23;24(4):810. 2. Tatton WG, et, al. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology. 1996 Dec;47(6 Suppl 3):S171-83. 3. MohanKumar PS, et, al. Deprenyl stimulates the efflux of monoamines from the rat hypothalamus in vitro. Brain Res Bull. 2001 Apr;54(6):675-80. 4. Ho MC, et, al. Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice. Psychopharmacology (Berl). 2009 Jul;205(1):141-9.

溶解性：

DMSO : 200 mg/mL (893.89 mM; Need ultrasonic) H2O : ≥ 33.33 mg/mL (148.97 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.469 ml	22.347 ml	44.694 ml
5 mM	0.894 ml	4.469 ml	8.939 ml
10 mM	0.447 ml	2.235 ml	4.469 ml
50 mM	0.089 ml	0.447 ml	0.894 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(2篇)

2. [IF=6.6] Michael Edbert Suryanto et al."Antidepressant Screening Demonstrated Non-Monotonic Responses to Amitriptyline, Amoxapine and Sertraline in Locomotor Activity Assay in Larval Zebrafish."Cells-Basel. 2021 Apr;10(4):738 1. Suryanto, Michael Edbert, et al. "Antidepressant Screening Demonstrated Non-Monotonic Responses to Amitriptyline, Amoxapine and Sertraline in Locomotor Activity Assay in Larval Zebrafish." Cells 10.4 (2021): 738.https://doi.org/10.3390/cells10040738

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Selegiline hydrochloride