AG-1478 (Tyrphostin AG-1478)

99.90%

4-(3-Chloroanilino)-6,7-Dimethoxyquinazoline Hydrochloride

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品牌：源叶(MedMol)

产品编号：S80398 一键复制产品信息

CAS号：153436-53-4

分子式：C₁₆H₁₅Cl₂N₃O₂

分子量：352.2

别名：次黄嘌呤.6-羟基嘌呤; 6-羟基嘌呤;;AG-1478 hydrochloride; Tyrphostin AG 1478; AG-1478;

AG-1478 (Tyrphostin AG-1478)（153436-53-4）

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80398-2mg	99.90%	￥216.00 S80398-2mg ￥216.00 现货	5 5	-	-	-	-
S80398-5mg	99.90%	￥304.00 S80398-5mg ￥304.00 现货	6 6	-	-	-	-
S80398-10mg	99.90%	￥420.00 S80398-10mg ￥420.00 现货	5 5	-	-	-	-
S80398-25mg	99.90%	￥800.00 S80398-25mg ￥800.00 现货	6 6	-	-	-	-
S80398-50mg促销	99.90%	￥1200.00 ￥960.00 S80398-50mg ￥960.00 现货	6 6	-	-	-	-
S80398-100mg促销	99.90%	￥2240.00 ￥1790.00 S80398-100mg ￥1790.00 现货	2 0 2	-	-	-	-
S80398-200mg促销	≥99%	￥3200.00 ￥2560.00 S80398-200mg ￥2560.00 2-3天	0 货期：2-3天	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).

靶点：

EGFR:3 nM (IC50);HCV;EMCV ;EGFR;HCVProtease;InfluenzaVirus;HER;PDGFR

体内研究：

Administration of AG-1478 (AG1478) significantly reduces myocardial inflammation, fibrosis, apoptosis, and dysfunction in both two obese mouse models. ApoE-/- mice are first fed with HFD for 8 weeks (ApoE-HFD), and then administrated with AG-1478 (10 mg/kg/day) or 542 (10 mg/kg/day) for another 8 weeks by oral gavage. AG-1478 or 542 treatment blocks HFD induced cardiac EGFR phosphorylation in vivo, without affecting the plasma level of low density lipoprotein (LDL) and total triglyceride (TG). Administration of EGF (10 nM) leads to a robust and reproducible elevation in EGFR phosphorylation that can be blocked by AG-1478 (AG1478), a known inhibitor of EGFR phosphorylation. Increasing doses of Polyfect (PF) result in a significant reduction in EGF-induced EGFR phosphorylation (p<0.05) but this is to a lesser extent than observed with AG1478

参考文献：

1. Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50(2):186-95. 2. Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. 3. Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215. 4. Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6.

溶解性：

DMSO : 50 mg/mL (158.35 mM; Need ultrasonic)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.839 ml	14.196 ml	28.393 ml
5 mM	0.568 ml	2.839 ml	5.679 ml
10 mM	0.284 ml	1.42 ml	2.839 ml
50 mM	0.057 ml	0.284 ml	0.568 ml