A-779

99.10%

(D-ALA7)-ANGIOTENSIN I/II (1-7)

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品牌：源叶(MedMol)

产品编号：S80413 一键复制产品信息

CAS号：159432-28-7

分子式：C₃₉H₆₀N₁₂O₁₁

分子量：872.967

别名：A-779;H-ASP-ARG-VAL-TYR-ILE-HIS-D-ALA-OH;DRVYIHA;(D-ALA7)-ANGIOTENSIN I/II (1-7);ASP-ARG-VAL-TYR-ILE-HIS-D-ALA;(D-Ala7)-Angiotensin I/II (1-7) A-779

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80413-1mg买3赠1	99.10%	￥290.00 S80413-1mg ￥290.00 现货（买3赠1）	9 9	-	-	-	-
S80413-5mg买3赠1	99.10%	￥350.00 S80413-5mg ￥350.00 现货（买3赠1）	6 6	-	-	-	-
S80413-10mg买3赠1	99.10%	￥580.00 S80413-10mg ￥580.00 现货（买3赠1）	6 6	-	-	-	-
S80413-50mg买3赠1	99.10%	￥1760.00 S80413-50mg ￥1760.00 现货（买3赠1）	5 5	-	-	-	-
S80413-100mg买3赠1	99.10%	￥2770.00 S80413-100mg ￥2770.00 现货（买3赠1）	4 0 4	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor distinct from the classical AngII.

靶点：

Angiotensin Receptor;RAAS

体内研究：

Infusion of Ang(1-7) and A-779 (400 ng/kg/min, s.c.) alone or combined for 6 weeks does not prevent uterus atrophy or inhibit the body weight gain of OVX rats. A-779 markedly elevates serum bone specific alkaline phosphatase (BALP), telopeptides of collagen type I (CTX), tartarate resistant acid phosphatase (TRAcP 5b), osteocalcin (OC) and urinary deoxypyridinoline (DPD). Infusion of Ang(1-7) and/or A-779 does not significantly change serum minerals concentrations in sham or OVX groups. A-779 in the OVX animals does not change AngII, Ang(1-7), AT1R, AT2R, ACE, ACE-2, Mas receptor, RANKL and OPG proteins expressions in relation to OVX group, while AngII (P < 0.05), AT1R (P < 0.05), ACE (P < 0.01) and RANKL (P < 0.01) expressions are significantly higher and Ang(1-7), AT2R, ACE-2, MasR and OPG are significantly (P < 0.01) lower than sham group. Blocking of the G-protein coupled receptor (Mas) by A-779 markedly abolishes Ang(1-7) favorable effects on bone health suggesting the vital role of Mas receptor in mediating Ang(1-7) osteo-protective effects. Inhibition of Ang1-7 cascade by A-779 (400 ng/kg/min) significantly eradicates captopril protective effects on bone metabolism, mineralization and micro-structure. A-779 also restores OVX effects on RANKL expression and ACE-1/AngII/AT1R cascade and down-regulates OPG expression and ACE-2/Ang1-7/Mas pathway

参考文献：

1. Abuohashish HM, et al. Angiotensin (1-7) ameliorates the structural and biochemical alterations of ovariectomy-induced osteoporosis in rats via activation of ACE-2/Mas receptor axis. Sci Rep. 2017 May 23;7(1):2293. 2. Abuohashish HM, et al. ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats. Biomed Pharmacother. 2017 Aug;92:58-68. 3. Yan WF, et al. Effects and related mechanism of angiotensin-(1-7) on Toll-like receptor 4-mediated oxidative stress in human umbilical vein endothelial cells. Zhonghua Xin Xue Guan Bing Za Zhi. 2017 Mar 24;45(3):223-229.

溶解性：

0.1 M HCL : 25 mg/mL (28.64 mM; ultrasonic and adjust pH to 1 with HCl) H2O : 5 mg/mL (5.73 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.146 ml	5.728 ml	11.455 ml
5 mM	0.229 ml	1.146 ml	2.291 ml
10 mM	0.115 ml	0.573 ml	1.146 ml
50 mM	0.023 ml	0.115 ml	0.229 ml