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产品描述： ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM). |
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靶点：
PERK:5 nM (IC50);Apoptosis;PERK;Autophagy |
体内研究：
ISRIB increases long-term memory in rodents. ISRIB-treated mice display significant enhancement in spatial and fear-associated learning. ISRIB displays a half-life in plasma of 8 hr and readily crossed the blood-brain barrier, quickly equilibrating with the central nervous system |
参考文献：
1. Sidrauski C, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28;2:e00498. 2. Sidrauski C, et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stressgranule assembly. Elife. 2015 Feb 26;4. doi: 10.7554/eLife.05033. |
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溶解性：
DMSO : 4.55 mg/mL (10.08 mM; ultrasonic and warming and heat to 60°C) |
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保存条件：
2-8℃ |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
2.216 ml |
11.078 ml |
22.156 ml |
| 5 mM |
0.443 ml |
2.216 ml |
4.431 ml |
| 10 mM |
0.222 ml |
1.108 ml |
2.216 ml |
| 50 mM |
0.044 ml |
0.222 ml |
0.443 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京