货号	规格	价格	上海	北京	武汉	南京
S80421-2mg	99.6%	￥240.00 S80421-2mg ￥240.00 现货	4 4	-	-	-
S80421-5mg	99.6%	￥320.00 S80421-5mg ￥320.00 现货	5 5	-	-	-
S80421-10mg	99.6%	￥390.00 S80421-10mg ￥390.00 现货	2 2	-	-	-
S80421-25mg	99.6%	￥782.00 S80421-25mg ￥782.00 现货	5 5	-	-	-
S80421-50mg	99.6%	￥1360.00 S80421-50mg ￥1360.00 现货	6 6	-	-	-
S80421-100mg	99.6%	￥1650.00 S80421-100mg ￥1650.00 现货	4 4	-	-	-

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产品介绍

TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).

产品描述：

TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).

靶点：

IC50: 5 nM (MTH1);DNA/RNASynthesis;MTH1

体外研究：

TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM. Cell Viability Assay[1] Cell Line: U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells Concentration: 2, 4, 6, 8, 10 μM Incubation Time: 7-10 days Result: Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM, but was less toxic to several primary or immortalized cells.

体内研究：

TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model. Animal Model: 5-6 weeks female SCID mice (SW480 xenograft cancer model) Dosage: 30 mg/kg Administration: Subcutaneous injection; once daily for 35 days Result: Reduced tumour growth in SW480 xenograft cancer model.

参考文献：

1. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.388 ml	16.94 ml	33.879 ml
5 mM	0.678 ml	3.388 ml	6.776 ml
10 mM	0.339 ml	1.694 ml	3.388 ml
50 mM	0.068 ml	0.339 ml	0.678 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=18] Cui Ren et al."DNA-mediated self-assembly oxidative damage amplifier combined with copper and MTH1 inhibitor for cancer therapy."Bioactive Materials.2025 Mar;45:434

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