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• 产品描述： TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).

• 靶点： IC50: 5 nM (MTH1);DNA/RNASynthesis;MTH1

• 体外研究：
  TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM. Cell Viability Assay[1] Cell Line: U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells Concentration: 2, 4, 6, 8, 10 μM Incubation Time: 7-10 days Result: Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM, but was less toxic to several primary or immortalized cells.

• 体内研究：
  TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model. Animal Model: 5-6 weeks female SCID mice (SW480 xenograft cancer model) Dosage: 30 mg/kg Administration: Subcutaneous injection; once daily for 35 days Result: Reduced tumour growth in SW480 xenograft cancer model.

• 参考文献：
  1. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.388 ml	16.94 ml	33.879 ml
  5 mM	0.678 ml	3.388 ml	6.776 ml
  10 mM	0.339 ml	1.694 ml	3.388 ml
  50 mM	0.068 ml	0.339 ml	0.678 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *