ALLOPURINOL RIBOSIDE

    
99%

ALLOPURINOL RIBOSIDE

源叶(MedMol)
S80426 一键复制产品信息
16220-07-8
C10H12N4O5
268.226
1-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE-4-ONE;1-BETA-D-RIBOFURANOSYLPYRAZOLO[3,4-D]PYRIMIDIN-4-ONE;ALLOPURINOL RIBOSIDE;8-AZA-7-DEAZAINOSINE;1-β-d-ribofuranosyl-1h-pyrazolo[3,4-d]pyrimidi
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80426-5mg 99% ¥1200.00 货期:2-3天 - - -
S80426-25mg 99% ¥3200.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

产品描述: Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.
靶点: Leishmania;EndogenousMetabolite;Parasite;DrugMetabolite
体内研究: Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 hours, and steady-state concentrations in the therapeutic range. After oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma
参考文献: 1. Nishida Y, et al. Inhibition of purine nucleoside phosphorylase activity and of T-cell function with allopurinol-riboside. Agents Actions. 1979 Dec;9(5-6):549-52. 2. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. 3. Shapiro TA, et al. Pharmacokinetics and metabolism of allopurinol riboside. Clin Pharmacol Ther. 1991 May;49(5):506-14. 4. Were JB, et al. Effects of probenecid on the pharmacokinetics of allopurinol riboside. Antimicrob Agents Chemother. 1993 May;37(5):1193-6.
溶解性: Soluble  in  DMSO
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.728 ml 18.641 ml 37.282 ml
5 mM 0.746 ml 3.728 ml 7.456 ml
10 mM 0.373 ml 1.864 ml 3.728 ml
50 mM 0.075 ml 0.373 ml 0.746 ml
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参考文献

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摩尔浓度计算器

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