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产品描述： ITSA-1 is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA)-induced cell cycle arrest, histone acetylation, and transcriptional activation |
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靶点：
HDAC |
体内研究：
ITSA-1 (0.5 mg/kg; intraperitoneal injection; 3 times/week; for 8 weeks; CBS+/− mice) treatment balances deacetylation activity and suppresses IL-6 and TNF-α expression and thereby attenuated histone acetylationdependent infammatory signaling |
参考文献：
1. Koeller KM et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histoneand tubulin acetylation. Chem Biol. 2003 May;10(5):397-410. 2. Behera J, et al. Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism. Sci Rep. 2018 Oct 15;8(1):15226. |
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溶解性：
DMSO : ≥ 32 mg/mL (109.54 mM) |
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保存条件：
RT |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
3.423 ml |
17.116 ml |
34.233 ml |
| 5 mM |
0.685 ml |
3.423 ml |
6.847 ml |
| 10 mM |
0.342 ml |
1.712 ml |
3.423 ml |
| 50 mM |
0.068 ml |
0.342 ml |
0.685 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京