| 产品描述： | Oxibendazole is an effective benzimidazole anthelmintic and is against nema-tode infections. Oxibendazole can induces apoptosis and has anti-cancer and anti-inflammation activities |
| 靶点： |
Apoptosis;Parasite |
| 体外研究： |
Cell proliferation decreased in both porcine trophectoder (pTr) and Porcine luminal epithelial (pLE) cells in response to Oxibendazole, and we determines that this is modulated through intracellular cell signal transduction. Phosphorylation of ERK1/2, P90RSK, and S6 are downregulated by exposure to a 200 nM dose of Oxibendazole in both types of cells, while the expression of phosphorylated JNK, AKT, and P70S6K is upregulated. |
| 体内研究： |
The mean size of 22Rv1 tumors in nude mice treated with Oxibendazole (25 mg/kg/day) is 47.96% smaller than that of the control mice. Treatment with Oxibendazole increases the expression of microRNA-204 (miR-204). |
| 参考文献： |
1. Hahyun Park , et al.Oxibendazole induces apoptotic cell death in proliferating porcine trophectoderm and uterine luminal epithelial cells via mitochondria-mediated calcium disruption and breakdown of mitochondrial membrane potential. Comp Biochem Physiol C Toxicol Pharmacol. 2019 Jun;220:9-19. 2. Qiaoli Chen, et al. Oxibendazole inhibits prostate cancer cell growth. Oncol Lett. 2018 Feb;15(2):2218-2226. |
| 溶解性： |
Soluble in DMSO、H2O |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
4.012 ml |
20.059 ml |
40.117 ml |
| 5 mM |
0.802 ml |
4.012 ml |
8.023 ml |
| 10 mM |
0.401 ml |
2.006 ml |
4.012 ml |
| 50 mM |
0.08 ml |
0.401 ml |
0.802 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京