Micafungin Sodium

99.90%

sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-(4-(5-(4-(pe

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品牌：源叶(MedMol)

产品编号：S80530 一键复制产品信息

CAS号：208538-73-2

分子式：C₅₆H₇₀N₉NaO₂₃S

分子量：1292.26

别名：米卡芬净钠;米卡凡金钠; 米卡芬净钠盐;;Pneumocandin A0, 1-?[(4R,?5R)?-?4,?5-?dihydroxy-?N2-?[4-?[5-?[4-?(pentyloxy)?phenyl]?-?3-?isoxazolyl]?benzoyl]?-?L-?ornithine]?-?4-?[(4S)?-?4-?hydroxy-?4-?[4-?hydroxy-?3-?(sulfoox

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80530-2mg	99.90%	￥200.00 S80530-2mg ￥200.00 现货	3 3	-	-	-	-
S80530-5mg	99.90%	￥250.00 S80530-5mg ￥250.00 现货	5 5	-	-	-	-
S80530-10mg	99.90%	￥400.00 S80530-10mg ￥400.00 现货	13 >10	-	-	-	-
S80530-25mg	99.90%	￥850.00 S80530-25mg ￥850.00 现货	7 0 7	-	-	-	-
S80530-50mg	99.90%	￥1600.00 S80530-50mg ￥1600.00 现货	7 7	-	-	-	-
S80530-100mg	≥99%(HPLC)	￥3000.00 S80530-100mg ￥3000.00 2-3天	0 货期：2-3天	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Micafungin Sodium is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity.

靶点：

Antibiotic;Antifungal

体外研究：

Micafungin (10 mg/mL) phenotypicly decreases the formation of biofilm in most of the isolates. For all the genes tested, the levels of mRNA transcription are also decreased significantly in micafungin-treated samples cf. their untreated counterparts. The combination of micafungin and KB425796-C is fungicidal and markedly reduces the number of CFU, in contrast to the fungistatic effects (no reduction in CFU) observed at all examined time points when each drug is used alone.

体内研究：

Micafungin (1 mg/kg) significantly prolongs survival compared with mice administered saline. Animals given a combination of micafungin (0.1 mg/kg) and KB425796-C (32 mg/kg) show a trend towards prolonged survival in comparison with those treated with micafungin (0.1 mg/kg) alone. In the livers of micafungin-treated mice, the number of CFUs decreases, although the clearance effect is less than that found in the kidneys. Combination treatment with micafungin and KB425796-C results in a significant decrease in the number of CFUs compared with the treatment with micafungin alone at all examined doses. The clearance effect associated with KB425796-C in combination with micafungin is greater than that observed in AMPH-treated animals.

细胞实验：

Each fungal isolate is incubated statically in yeast-maltose (YM) agar broth for 24 h at 30°C. Cryptococcus neoformans YC203 is grown in YM broth medium for 20 h at 30°C with shaking at 200 r.p.m. A cell suspension is prepared by washing the cultured cells once with sterile saline. A. fumigatus FP1305 is cultured on a potato dextrose agar (PDA) slant for 4 days, and spores are then harvested in sterile saline and collected by filtering through gauze. Antifungal activity against all isolates, with the exception of C. neoformans, is measured by the micro-broth dilution method in 96-well culture plates using RPMI 1640 medium supplemented with l-glutamine, but without sodium bicarbonate, and buffered to pH 7.0 with 0.165 m MOPS. ForC. neoformans, yeast nitrogen base-glucose (YNBD) medium is used. For the assay, the test microorganism is inoculated into each well to yield 1×105 CFU/well, and the plates are then incubated for 20 h or 48 h at 37°C. Two end points are determined by microscopic observation: MEC, which

参考文献：

1. Tsang C C, Tang J Y M, Ye H, et al. Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing[J]. Mycoses. 2020, 63(12): 1283-1298. 2. Kai H, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigat us and its efficacy in murine infection models. J Antibiot (Tokyo). 2013 Jun 12. 3. Bazzi W, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling. 2013 Jul 23. 4. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing[J]. Emerging microbes & infections. 2019;8(1):531-541.

溶解性：

Soluble in DMSO、H2O

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.774 ml	3.869 ml	7.738 ml
5 mM	0.155 ml	0.774 ml	1.548 ml
10 mM	0.077 ml	0.387 ml	0.774 ml
50 mM	0.015 ml	0.077 ml	0.155 ml