Tulathromycin A

98.50%

Tulathromycin A

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品牌：源叶(MedMol)

产品编号：S80543 一键复制产品信息

CAS号：217500-96-4

分子式：C₄₁H₇₉N₃O₁₂

分子量：806.08

别名：托拉菌素 A;托拉菌素A,土拉霉素A; 土拉霉素A; 土拉霉素 A;;(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-a-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80543-5mg买3赠1	98.50%	￥110.00 S80543-5mg ￥110.00 现货（买3赠1）	2 4 2	4	-	-	-
S80543-10mg买3赠1	98.50%	￥180.00 S80543-10mg ￥180.00 现货（买3赠1）	5 5	-	-	-	-
S80543-50mg买3赠1	98.50%	￥590.00 S80543-50mg ￥590.00 现货（买3赠1）	1 1	-	-	-	-
S80543-100mg买3赠1	98.50%	￥860.00 S80543-100mg ￥860.00 现货（买3赠1）	3 3	-	-	-	-
S80543-1g买3赠1	98.50%	￥4500.00 S80543-1g ￥4500.00 现货（买3赠1）	8 8	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Tulathromycin A (Tulathromycin), a macrolide antibiotic, inhibits protein synthesis (IC50=0.26 µM) by targeting bacterial ribosome. Tulathromycin A is used for the research of respiratory disease in cattle and swine. Immunomodulatory effects

靶点：

Macrolide;Antibacterial;Antibiotic

体内研究：

In the lungs of both A pleuropneumoniae- and zymosan-challenged pigs, Tulathromycin A (2.5 mg/kg, IM) promotes leukocyte apoptosis and efferocytosis and inhibites proinflammatory leukotriene B4 production, with a concurrent reduction in leukocyte necrosis relative to that of control pigs. Tulathromycin A also attenuates the degree of lung damage and lesion progression in A pleuropneumoniae-inoculated pigs

参考文献：

1. Villarino N, et al. Pharmacokinetics of tulathromycin in healthy and neutropenic mice challenged intranasally with lipopolysaccharide from Escherichia coli. Antimicrob Agents Chemother. 2012;56(8):4078-4086. 2. Andersen NM, et al. Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. Antimicrob Agents Chemother. 2012;56(11):6033-6036. 3. Duquette SC, et al. Immunomodulatory effects of tulathromycin on apoptosis, efferocytosis, and proinflammatory leukotriene B4 production in leukocytes from Actinobacillus pleuropneumoniae-or zymosan-challenged pigs. Am J Vet Res. 2015;76(6):507-519.

溶解性：

DMSO : 50 mg/mL (62.03 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.241 ml	6.203 ml	12.406 ml
5 mM	0.248 ml	1.241 ml	2.481 ml
10 mM	0.124 ml	0.62 ml	1.241 ml
50 mM	0.025 ml	0.124 ml	0.248 ml