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S80550

Zotarolimus

源叶(MedMol) 98%
  • 英文名:
  • Zotarolimus
  • 别名:
  • 佐他莫司; 他莫司;;zotarolimus
  • CAS号:
  • 221877-54-9
  • 分子式:
  • C52H79N5O12
  • 分子量:
  • 966.21
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S80550-1mg 98% ¥305.00元 10 - - - EA 加入购物车
源叶(MedMol) S80550-5mg 98% ¥884.00元 >10 - - - EA 加入购物车
源叶(MedMol) S80550-25mg 98% ¥2502.40元 6 - - - EA 加入购物车
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参考文献

质检证书(COA)

摩尔浓度计算器

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  • 提示:详情请下载说明书。
  • 产品描述: Zotarolimus, an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).
  • 靶点: mTOR
  • 体内研究:
    Zotarolimus potently inhibits adjuvant DTH(ED50=1.72 mg/kg/day), EAE(ED50=1.17 mg/kg/day), and cardiac allograft rejection(ED50=3.71 mg/kg/day)
  • 细胞实验: Cell proliferation is assayed by measuring tritiated thymidine incorporation in vitro. Human coronary artery cells (hCa) are seeded into tissue culture flasks for expansion and applied to 96-well plates at desired density in complete media (5000 hCaSMC; 10 000 hCaEC). After 2 days, complete media is replaced with incomplete media to synchronize cells and induce G0 state. Two days later, incomplete media are removed and replaced with complete media (serum/growth factors) to induce G0 to G1 transition. Complete media also contain drug at desired concentrations to determine its effects on cell proliferation. On day 7, 3H-thymidine is added to cells to monitor DNA synthesis, and cells are harvested after overnight incorporation of radioactivity. After an incubation period of 72 h, 25 μL (1 μCi/well) of 3H-thymidine are added to each well. The cells are incubated at 37°C for 16-18 h to allow for incorporation of 3H-thymidine into newly synthesized DNA and the cells harvested onto 96-well plates containing bonded g
  • 动物实验: Male Sprague-Dawley rats was administrate by intravenous or oral Zotarolimus(2.5 mg/kg)dissolved inethanol: propylene glycol: cremophor EL: D5W vehicle (20: 30: 2: 48, by volume).
  • 参考文献:
    1.Chen YW, et al. J Cardiovasc Pharmacol, 2007, 49(4), 228-235. 2.Garcia-Touchard A, et al. Eur Heart J, 2006, 27(8), 988-1993.
  • 溶解性: Ethanol:93  mg/mL  (96.3  mM)    H2O:<1  mg/mL    DMSO:93  mg/mL  (96.3  mM)
  • 保存条件: 2-8℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 1.035 ml 5.175 ml 10.35 ml
    5 mM 0.207 ml 1.035 ml 2.07 ml
    10 mM 0.103 ml 0.517 ml 1.035 ml
    50 mM 0.021 ml 0.103 ml 0.207 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)


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