| 产品描述： | Difluprednate(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain. |
| 体内研究： |
Difluprednate emulsion is rapidly deacetylated in the aqueous humor to difluoroprednisolone butyrate (DFB) in rats and rabbits, the drug's active metabolite, which has a similar corticosteroid activity profile. Radio-labeled difluprednate is instilled in the right eyes of pigmented rabbits in a separate study examining DFBA excretion. Difluprednate (0.05% emulsion) results in higher aqueous humor concentrations than the suspension form in the eyes of rabbits. Difluprednate concentrations ≥0.01% shows a statistically significant inhibition of inflammation compared to saline in a rabbit model, with the anti-inflammatory response proceeding in a dose-dependent manner. Difluprednate suppresses uveitis in all three concentration (0.002%, 0.01%, and 0.05%) in a dose-dependent manner in rats, and difluprednate 0.05% shows statistically superior anti-inflammatory activity compared to Betamethasone (0.1%). |
| 参考文献： |
1. Donnenfeld ED, et al. Clin Ophthalmol, 2011, 5, 811-816. 2.Jamal KN, et al. Clin Ophthalmol, 2009, 3, 381-390. |
| 溶解性： |
Soluble in DMSO、Ethanol |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.966 ml |
9.832 ml |
19.664 ml |
| 5 mM |
0.393 ml |
1.966 ml |
3.933 ml |
| 10 mM |
0.197 ml |
0.983 ml |
1.966 ml |
| 50 mM |
0.039 ml |
0.197 ml |
0.393 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京