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• 产品描述： Difluprednate(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.

• 体内研究：
  Difluprednate emulsion is rapidly deacetylated in the aqueous humor to difluoroprednisolone butyrate (DFB) in rats and rabbits, the drug's active metabolite, which has a similar corticosteroid activity profile. Radio-labeled difluprednate is instilled in the right eyes of pigmented rabbits in a separate study examining DFBA excretion. Difluprednate (0.05% emulsion) results in higher aqueous humor concentrations than the suspension form in the eyes of rabbits. Difluprednate concentrations ≥0.01% shows a statistically significant inhibition of inflammation compared to saline in a rabbit model, with the anti-inflammatory response proceeding in a dose-dependent manner. Difluprednate suppresses uveitis in all three concentration (0.002%, 0.01%, and 0.05%) in a dose-dependent manner in rats, and difluprednate 0.05% shows statistically superior anti-inflammatory activity compared to Betamethasone (0.1%).

• 参考文献：
  1. Donnenfeld ED, et al. Clin Ophthalmol, 2011, 5, 811-816. 2.Jamal KN, et al. Clin Ophthalmol, 2009, 3, 381-390.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.966 ml	9.832 ml	19.664 ml
  5 mM	0.393 ml	1.966 ml	3.933 ml
  10 mM	0.197 ml	0.983 ml	1.966 ml
  50 mM	0.039 ml	0.197 ml	0.393 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *