产品描述: Anamorelin (RC-1291) is a potent ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay. |
靶点:
Ki: 0.7 nM (ghrelin receptor) EC50: 0.74 nM (ghrelin receptor);GHSR |
体内研究:
In rats, Anamorelin (ANAM) at an oral dose of 3, 10, or 30 mg/kg once daily significantly increases both food intake and body weight from Day 2 to Day 7 of treatment compared with the vehicle control. The cumulative change in food intake and weight gain increases dose-dependently, and these changes are significant at all dose levels (P<0.05) compared to the control. Administration of Anamorelin at a single oral dose of 3, 10, or 30 mg/kg induces a dose-dependent increase in plasma GH levels and GH AUC0-6h in rats |
参考文献:
1. Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):329-37. |
溶解性:
DMSO : ≥ 100 mg/mL (182.92 mM) |
保存条件:
-20℃ |
配置溶液浓度参考:
|
1mg |
5mg |
10mg |
1 mM |
1.829 ml |
9.146 ml |
18.292 ml |
5 mM |
0.366 ml |
1.829 ml |
3.658 ml |
10 mM |
0.183 ml |
0.915 ml |
1.829 ml |
50 mM |
0.037 ml |
0.183 ml |
0.366 ml |
|
注意: |
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