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• 产品描述： XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation

• 靶点： TNKS2:2 nM (IC50);TNKS1:5 nM (IC50);ARTD2:479 nM (IC50)；ARTD1：5500 nM (IC50);PARP;Wnt/beta-catenin

• 体内研究：
  XAV-939 rescues mechanical stress-induced cartilage degeneration in vivo

• 参考文献：
  1. Mohit Narwal, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9. 2. Nuha Almasoud, et al. Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells. Sci Rep. 2020 Oct 7;10(1):16746. 3. Senxin Cai, et al. Mechanical stress reduces secreted frizzled-related protein expression and promotes temporomandibular joint osteoarthritis via Wnt/β-catenin signaling. Bone. 2022 Aug;161:116445.

• 溶解性： DMSO  :  15.62  mg/mL  (50.01  mM;  ultrasonic  and  warming  and  heat  to  60°C)    H2O  :  <  0.1  mg/mL  (insoluble)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.202 ml	16.01 ml	32.019 ml
  5 mM	0.64 ml	3.202 ml	6.404 ml
  10 mM	0.32 ml	1.601 ml	3.202 ml
  50 mM	0.064 ml	0.32 ml	0.64 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=2.751] Shixiong Lei et al."CRP‑1 promotes the malignant behavior of hepatocellular carcinoma cells via activating epithelial‑mesenchymal transition and Wnt/β‑catenin signaling."Experimental and Therapeutic Medicine.2023 Jul;26(1):1-10

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *