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NPS-2143 99%

NPS-2143

源叶(MedMol)
S80588
284035-33-2
C24H25ClN2O2
408.93
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80588-5mg 99% ¥290.00元 6 - - -
源叶(MedMol) S80588-10mg 99% ¥530.00元 2 - - -
源叶(MedMol) S80588-50mg 99% ¥1972.00元 4 - - -
源叶(MedMol) S80588-100mg 99% ¥3264.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor
产品描述: NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor
靶点: IC50: 43 nM (Ca2+ receptor);CalciumChannel;CaSR
体内研究:
NPS-2143 (SB-262470A) results in a rapid 4- to 5-fold increase in plasma PTH levels in rats. In normotensive rats, NPS-2143 administration (1 mg/kg, i.v.) markedly increases mean arterial blood pressure (MAP) in the presence of parathyroid glands.
参考文献:
1. Nemeth EF, et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31. 2. Rybczynska A, et al. Hypertensive effect of calcilytic NPS 2143 administration in rats. J Endocrinol. 2006 Oct;191(1):189-95. 3. Ohsu T, et al. Involvement of the calcium-sensing receptor in human taste perception. J Biol Chem. 2010 Jan 8;285(2):1016-22 4. Nakajima S, et al. Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells. Mol Nutr Food Res. 2012 May;56(5):753-60 5. Sun J, et al. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1309-17.
溶解性: DMSO  :  17.86  mg/mL  (43.68  mM;  ultrasonic  and  adjust  pH  to  2  with  H2O)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.445 ml 12.227 ml 24.454 ml
5 mM 0.489 ml 2.445 ml 4.891 ml
10 mM 0.245 ml 1.223 ml 2.445 ml
50 mM 0.049 ml 0.245 ml 0.489 ml
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参考文献

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