Triciribine

    
99%

Triciribine

源叶(MedMol)
S80679 一键复制产品信息
35943-35-2
C13H16N6O4
320.30
6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80679-5mg 99% ¥476.00 >10 - - -
S80679-10mg 99% ¥761.60 >10 - - -
S80679-50mg 99% ¥2584.00 >10 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.

产品描述: Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
靶点: HIV-1;HIV-2;DNA synthesis;HIV-1:0.02-0.46 μM (IC50);HIV-2:0.02-0.46 μM (IC50);Akt;HIVProtease;DNA/RNASynthesis
体内研究: Triciribine (TCBN) treatment, administered for 7 days after 14 days of hypoxia until 21 days of hypoxia is reached, reversed the vascular thickening as shown by immunohistochemistry and Western analyses. On the other hand, Rapamycin treatment did not prevent hypoxia-induced pulmonary alveolar haemorrhage and congestion. Triciribine partially inhibits progressive pruning of the vasculature
参考文献: 1. Dieterle A, et al. The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. Int J Cancer. 2009 Aug 15;125(4):932-41. 2. Gürsel DB, et al. Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma. Neuro Oncol. 2011 Jun;13(6):610-21 3. Kucera LS, et al. Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2. AIDS Res Hum Retroviruses. 1993 Apr;9(4):307-14. 4. Abdalla M, et al. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis. Br J Pharmacol. 2015 Aug;172(16):4173-88.
溶解性: DMSO  :  100  mg/mL  (312.21  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.122 ml 15.61 ml 31.221 ml
5 mM 0.624 ml 3.122 ml 6.244 ml
10 mM 0.312 ml 1.561 ml 3.122 ml
50 mM 0.062 ml 0.312 ml 0.624 ml
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参考文献

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