• 产品描述： Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning

• 靶点： Cholinesterase (ChE)

• 体内研究：
  Pralidoxime chloride (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice

• 参考文献：
  1. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. 2. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. 3. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138.

• 溶解性： H2O  :  ≥  100  mg/mL  (579.34  mM)    DMSO  :  21.67  mg/mL  (125.54  mM;  Need  ultrasonic)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	5.793 ml	28.967 ml	57.934 ml
  5 mM	1.159 ml	5.793 ml	11.587 ml
  10 mM	0.579 ml	2.897 ml	5.793 ml
  50 mM	0.116 ml	0.579 ml	1.159 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *