| 产品描述： | Metoclopramide hydrochloride hydrate is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide hydrochloride hydrate can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis |
| 靶点： |
5-HT3 Receptor:308 nM (IC50);D2 Receptor:483 nM (IC50);DopamineReceptor;5-HTReceptor |
| 体内研究： |
Metoclopramide (6.7 µg/g; s.c. daily for 50 days) hydrochloride hydrate significantly increases the number and the volume of lactotroph cells of the pituitary gland during all phases of the estrous cycle. Metoclopramide (5-40 mg/kg; i.p.) hydrochloride hydrate induces catalepsy and antagonizes Apomorphine induced cage climbing behaviour in mice. Metoclopramide (1.25-2.5 mg/kg; i.p.) hydrochloride hydrate induces stereotyped cage climbing behaviour in mice. |
| 参考文献： |
1. Hirokawa Y, et, al. Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist. Chem Pharm Bull 2. Rao AS, et, al. Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther. 2010 Jan;31(1):11-9. 3. Edwards CR, et, al. In vivo and in vitro studies on the effect of metoclopramide on aldosterone secretion. Clin Endocrinol (Oxf). 1980 Jul;13(1):45-50. 4. Bhosale KB, et, al. Dose-dependent response of central dopaminergic systems to metoclopramide in mice. Indian J Exp Biol. 1997 Jun;35(6):618-22. 5. Gomes RCT, et, al. Effects of metoclopramide on the mouse anterior pituitary during the estrous cycle. Clinics (Sao Paulo). 2011;66(6):1101-4. |
| 溶解性： |
DMSO : 50 mg/mL (141.14 mM; Need ultrasonic) H2O : 0.1 mg/mL (0.28 mM; Need ultrasonic) |
| 保存条件： |
RT |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.823 ml |
14.114 ml |
28.227 ml |
| 5 mM |
0.565 ml |
2.823 ml |
5.645 ml |
| 10 mM |
0.282 ml |
1.411 ml |
2.823 ml |
| 50 mM |
0.056 ml |
0.282 ml |
0.565 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京