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S80815

Azelastine

源叶(MedMol) 98%
  • 英文名:
  • Azelastine
  • 别名:
  • 氮卓斯汀;4-[(4-氯苯基)甲基]-2-(六氢-1-甲基-1H-氮杂卓)二氮杂萘酮;氮卓司丁;4-[(4-氯苯基)甲基]-2-(六氢-1-甲基-1H-氮杂卓-4-基)-1(2H)-酞嗪酮;氮卓司汀;4-[(4-氯苯基)甲基]-2-(六氢-1-甲基-1H-氮杂卓-4-基)二氮杂萘酮;氮卓斯丁;1(2H)-二氮杂萘酮,4-((4-氯苯基)甲基)-2-(六氢-1-甲基-1H-氮杂卓-4-基)-;1(2
  • CAS号:
  • 58581-89-8
  • 分子式:
  • C22H24ClN3O
  • 分子量:
  • 381.9
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S80815-100mg 98% ¥313.00元 4 - - - EA 加入购物车
源叶(MedMol) S80815-1g 98% ¥1742.50元 预计交期:2-3天 - - - EA 加入购物车
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参考文献(1篇)

质检证书(COA)

摩尔浓度计算器

相关产品

  • 产品描述: Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2
  • 靶点: H1 Receptor
  • 体内研究:
    Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model. Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model. Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model.
  • 参考文献:
    1. Craig La Force. Review of the pharmacology, clinical efficacy, and safety of azelastine hydrochloridel. Expert Rev Clin Immunol. 2005 Jul;1(2):191-201. 2. Mohamed M Elseweidy, et al. Azelastine a potent antihistamine agent, as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model. Arch Physiol Biochem. 2020 Jul 2;1-8. 3. Carlos D. Zappia, et al. Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model. Pharmacol Res Perspect. 2019 Dec; 7(6): e00531. 4. Li Yang, et al. Identification of SARS-CoV-2 entry inhibitors among already approved drugs. Acta Pharmacol Sin. 2020 Oct 28 : 1-7. 5. Shao-Cheng Liu, et al. Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells. Eur Arch Otorhinolaryngol. 2017 Feb;274(2):845-853.
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.618 ml 13.092 ml 26.185 ml
    5 mM 0.524 ml 2.618 ml 5.237 ml
    10 mM 0.262 ml 1.309 ml 2.618 ml
    50 mM 0.052 ml 0.262 ml 0.524 ml
  • 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
  • 1. Li, Meng, et al. "Chiral separation of five antihistamine drug enantiomers and enantioselective pharmacokinetic study of carbinoxamine in rat plasma by HPLC-MS/MS." New Journal of Chemistry 44.15 (2020): 5819-5827.https://doi.org/10.1039/D0NJ00095G
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