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产品描述： SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 Nm |
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靶点：
IC50: 110 nM (D1DR);DopamineReceptor |
体内研究：
SKF-38393 hydrochloride (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione. SKF-38393 hydrochloride attenuates MPTP-induced depletion of dopamine. SKF-38393 hydrochloride enhances the activity of superoxide dismutase and hence mimics the action of Selegiline. SKF-38393 hydrochloride enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action. |
参考文献：
1. Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7(1):213-222. 2. Mayerhofer A, et al. Functional Dopamine-1 Receptors and DARPP-32 Are Expressed in Human Ovary and Granulosa Luteal Cells in Vitro. J Clin Endocrinol Metab. 1999 Jan;84(1):257-64. 3. Muralikrishnan D, et al. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 2001 Feb 23;892(2):241-7. 4. Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-70. |
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溶解性：
DMSO : ≥ 34 mg/mL (116.53 mM) H2O : 10 mg/mL (34.27 mM; Need ultrasonic) |
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保存条件：
RT |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
3.427 ml |
17.136 ml |
34.272 ml |
| 5 mM |
0.685 ml |
3.427 ml |
6.854 ml |
| 10 mM |
0.343 ml |
1.714 ml |
3.427 ml |
| 50 mM |
0.069 ml |
0.343 ml |
0.685 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京